gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Afucosylated anti–IL-5Rα antibody binds CD125 on eosinophils/basophils and engages FcγRIIIa on NK cells to trigger potent ADCC (and some ADCP), leading to apoptosis/lysis of IL-5Rα+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Primary Fab target on eosinophils/basophils
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05847452
disease_id_num_tar_ref
3189
drug_id_num_tar_ref
8551