gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils and engages FcγRIIIa (CD16a) on NK cells to trigger ADCC, killing IL-5Rα+ cells; CD16a+ effector cells themselves are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement; afucosylated IgG1 Fc enhances affinity and ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05847452
disease_id_num_tar_ref
3189
drug_id_num_tar_ref
8551