gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug binds CD3 on T cells to activate them and bridge them to CD20+ B cells; T cells then kill the CD20+ targets via perforin/granzyme-mediated apoptosis. CD3+ cells are effectors, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Monovalent anti-CD3 arm in 2:1 CD20:CD3 bispecific
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05927558
disease_id_num_tar_ref
3192
drug_id_num_tar_ref
8556