gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds two HER2 epitopes on tumor cells, blocks HER2 dimerization/signaling causing apoptosis, and engages Fc receptors to elicit ADCC against HER2-expressing cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain subdomain II (dimerization domain); pertuzumab-like epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06023758
disease_id_num_tar_ref
3199
drug_id_num_tar_ref
8576