gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibodies bind mutant extracellular neoepitopes on tumor cells, engage Fcγ receptors on NK cells/macrophages to drive ADCC and phagocytosis, and activate complement for CDC, causing lysis of target-expressing cells.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain; neoepitope absent from normal tissue; patient-specific selection by tumor exome/RNA sequencing
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06674538
disease_id_num_tar_ref
283
drug_id_num_tar_ref
798