gene_symbol
GUCY2C
hgnc_id
HGNC:4688
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells recognize GUCY2C on target cells and, upon activation, kill them via perforin/granzyme-mediated cytotoxicity (HLA-independent).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain of membrane guanylate cyclase receptor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06718738
disease_id_num_tar_ref
3215
drug_id_num_tar_ref
8621