gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TIL recognize tumor peptide–HLA class I complexes via their endogenous TCRs and directly kill target cells through perforin/granzyme-mediated apoptosis (with possible Fas–FasL and cytokine contributions).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
peptide–MHC class I complex recognized by CD8+ TIL TCR; peptides may be neoantigens or shared TAAs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05831033
disease_id_num_tar_ref
3216
drug_id_num_tar_ref
8624