gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD38 IgG1 binds CD38 on target cells and triggers complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity (NK cells via FcγR), antibody-dependent cellular phagocytosis (macrophages), and can induce apoptosis, killing CD38+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface glycoprotein; ecto-enzyme (ADP-ribosyl cyclase/NADase)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06371534
disease_id_num_tar_ref
3221
drug_id_num_tar_ref
8639