gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 anti-EGFR antibody binds EGFR on tumor cells and recruits immune effectors via Fc–FcγR to mediate ADCC (and possibly CDC), killing EGFR+ cells; EGFR signaling blockade is antiproliferative.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain and blocks ligand binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06343116
disease_id_num_tar_ref
3229
drug_id_num_tar_ref
8659