gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Teclistamab binds CD3 on T cells to activate and redirect them to kill BCMA-expressing myeloma cells via perforin/granzyme cytotoxicity; CD3+ T cells themselves are not the lytic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds the CD3 epsilon subunit on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06465316
disease_id_num_tar_ref
3239
drug_id_num_tar_ref
8694