gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Inetetamab binds HER2 on tumor cells and its Fc engages Fcγ receptor–bearing effector cells (e.g., NK cells) to induce ADCC, leading to lysis of HER2-expressing cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (ECD); blocks HER2 dimerization/signaling; IgG1 Fc mediates ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06578299
disease_id_num_tar_ref
3244
drug_id_num_tar_ref
8705