gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2 on target cells and recruits FcγR-bearing immune cells to mediate ADCC; blockade of HER2 dimerization/signaling can also trigger apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular subdomain II (dimerization domain) to block HER2 dimerization and signaling; IgG1 Fc mediates ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06578299
disease_id_num_tar_ref
3244
drug_id_num_tar_ref
8706