gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on tumor cells and engages CD16a on NK cells via its Fc to trigger ADCC; CD16a+ cells act as effectors and are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement enabling NK cell ADCC; affinity influenced by FCGR3A V158F polymorphism
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05573893
disease_id_num_tar_ref
3250
drug_id_num_tar_ref
8726