gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 antibody binds HER2 on tumor cells and engages Fcγ receptor–bearing immune effectors (e.g., NK cells, macrophages) to mediate ADCC/ADCP, killing HER2+ cells; also blocks HER2 signaling (cytostatic).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trastuzumab-like epitope on extracellular domain IV
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06747338
disease_id_num_tar_ref
3255
drug_id_num_tar_ref
8735