gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2, blocks HER2 dimerization/signaling (inducing apoptosis) and engages FcγR-bearing effector cells to mediate ADCC against HER2+ cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds HER2 extracellular dimerization domain (subdomain II), blocking receptor dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06747338
disease_id_num_tar_ref
3255
drug_id_num_tar_ref
8738