gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Selective inhibition of HER2 kinase blocks PI3K/AKT/MAPK survival signaling in HER2+ cells, causing growth arrest and apoptosis.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ATP-competitive inhibition of the HER2 tyrosine kinase domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05458674
disease_id_num_tar_ref
286
drug_id_num_tar_ref
804