gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds TROP-2, is internalized, and releases SN-38, which inhibits topoisomerase I to cause DNA damage and apoptosis; membrane-permeable SN-38 can also produce bystander killing.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen targeted by antibody moiety
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05884320
disease_id_num_tar_ref
3263
drug_id_num_tar_ref
8762