gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets TROP-2 on tumor cells; after internalization, SN-38 is released and inhibits topoisomerase I to induce DNA damage and apoptosis. Killing is directed by TROP-2 binding, not by topoisomerase I expression itself (with potential bystander effect).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular enzyme targeted by SN-38 payload; stabilizes TOP1–DNA complexes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05884320
disease_id_num_tar_ref
3263
drug_id_num_tar_ref
8762