gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug binds CD3 on T cells to recruit/activate them; activated T cells kill DLL3-expressing tumor cells via perforin/granzymes, while CD3+ T cells are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engagement of CD3 on T cells to redirect cytotoxicity; specific chain not specified
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05879978
disease_id_num_tar_ref
3286
drug_id_num_tar_ref
8829