gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific ADC binds EGFR (and HER3), is internalized, and releases the topoisomerase I inhibitor brengitecan, causing DNA damage and tumor cell death (with possible bystander effect).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antigen target (cell-surface receptor tyrosine kinase)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05880706
disease_id_num_tar_ref
3295
drug_id_num_tar_ref
8847