gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds EGFR/HER3 (not Topoisomerase I), is internalized, and releases the topo I inhibitor brengitecan to cause DNA damage in EGFR/HER3-positive cells, with potential bystander killing.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular payload target (brengitecan; topoisomerase I inhibitor)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05880706
disease_id_num_tar_ref
3295
drug_id_num_tar_ref
8847