gene_symbol
ITGA3/ITGB1
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Recombinant bacterial minicells bind unligated α3β1 integrin on tumor cells and deliver the pore-forming toxin perfringolysin O, causing membrane disruption and rapid lysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
unligated conformation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05901285
disease_id_num_tar_ref
3299
drug_id_num_tar_ref
8857