gene_symbol
ITGA5/ITGB1
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
VAX014 binds un-ligated alpha5beta1 integrin on tumor cells and delivers perfringolysin O, a pore-forming toxin that disrupts the membrane and causes rapid cell lysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
unligated conformation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05901285
disease_id_num_tar_ref
3299
drug_id_num_tar_ref
8857