gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
EGFRt is a safety tag on the CAR-T cells; they are not targeted by the CAR. EGFRt+ CAR-T cells can be conditionally ablated only if an anti-EGFR antibody (e.g., cetuximab) is given, triggering ADCC/complement-mediated killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Safety/ablation tag recognized by cetuximab for conditional elimination
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05694364
disease_id_num_tar_ref
3305
drug_id_num_tar_ref
8879