gene_symbol
IDO1
hgnc_id
HGNC:6059
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Peptide vaccine induces IDO1-specific CD8+ (and CD4+) T cells that recognize IDO1 peptides on MHC of IDO1-expressing cells and kill them via CTL effector mechanisms (perforin/granzyme, Fas–FasL).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular enzyme; long-peptide vaccine induces TCR recognition of processed IDO1 epitopes presented on MHC class I and II.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05912244
disease_id_num_tar_ref
3314
drug_id_num_tar_ref
8905