gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
A peptide vaccine primes and expands PD-L1–specific CD8+ (and helper CD4+) T cells, which recognize PD-L1–derived peptides presented on MHC of PD-L1–expressing cells and kill them via T cell–mediated cytolysis (perforin/granzyme).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Long-peptide vaccine composed of PD-L1–derived epitopes that elicit PD-L1–specific CD4+/CD8+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05912244
disease_id_num_tar_ref
3314
drug_id_num_tar_ref
8906