gene_symbol
CD2
hgnc_id
HGNC:1639
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD2 IgG1 binds CD2+ lymphocytes and depletes them via Fc-mediated ADCC and complement-dependent cytotoxicity (CDC), causing lysis/apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks CD2–CD58 (LFA-3) costimulatory interaction; mediates ADCC/CDC to deplete CD2+ lymphocytes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05574335
disease_id_num_tar_ref
3322
drug_id_num_tar_ref
8936