gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds TROP-2, is internalized, and releases SN-38 (a topoisomerase I inhibitor) inside the cell, causing DNA damage, replication arrest, and apoptosis; can also produce a bystander effect.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06739395
disease_id_num_tar_ref
3323
drug_id_num_tar_ref
8944