gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds TROP‑2 on tumor cells, is internalized, and releases SN‑38, which inhibits topoisomerase I, stabilizing topo I–DNA complexes and causing DNA breaks and apoptosis (with possible bystander effect).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC payload target (SN-38)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06739395
disease_id_num_tar_ref
3323
drug_id_num_tar_ref
8944