gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TILs recognize the neoantigen peptide–HLA class I complex via native TCRs and directly kill target cells through MHC-restricted cytotoxicity (perforin/granzyme release and Fas–FasL–mediated apoptosis).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
MHC class I–restricted pMHC recognized by native CD8+ TCRs on TILs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06538012
disease_id_num_tar_ref
3325
drug_id_num_tar_ref
8954