gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TILs contain tumor‑reactive CD4+ T cells whose native TCRs recognize the peptide–HLA class II complex on target cells, triggering MHC II–restricted cytotoxicity via perforin/granzyme release and Fas–FasL–mediated apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
MHC class II–restricted pMHC recognized by native CD4+ TCRs on TILs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06538012
disease_id_num_tar_ref
3325
drug_id_num_tar_ref
8954