gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Avelumab binds PD-L1 on target cells and its IgG1 Fc engages Fc gamma receptors on NK cells to trigger antibody-dependent cellular cytotoxicity (ADCC), directly killing PD-L1-expressing cells; it also blocks PD-L1/PD-1 to restore CTL killing (indirect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks interaction of PD-L1 with PD-1 (PDCD1) and CD80 (B7.1); IgG1 Fc can mediate ADCC against PD-L1–expressing cells.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06424717
disease_id_num_tar_ref
3338
drug_id_num_tar_ref
8998