gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its Fc engages CD16a (FcγRIIIa) on NK cells/monocytes to trigger ADCC, killing CD20+ targets. CD16a-expressing effector cells are activated, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Afucosylated IgG1 Fc confers higher affinity; mediates ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06134284
disease_id_num_tar_ref
3339
drug_id_num_tar_ref
9002