gene_symbol
ERBB3
hgnc_id
HGNC:3431
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The HER3-targeted ADC binds ERBB3 on target cells, is internalized, and releases a topoisomerase I inhibitor payload that causes replication-associated DNA strand breaks leading to apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor; ADC antigen; internalization required
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06298058
disease_id_num_tar_ref
3340
drug_id_num_tar_ref
9003