gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Irreversible inhibition of EGFR/HER family kinase activity blocks MAPK/PI3K–AKT signaling, leading to growth arrest and apoptosis of EGFR-dependent tumor cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Irreversible covalent ATP-site inhibitor; pan-ERBB
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05834348
disease_id_num_tar_ref
3350
drug_id_num_tar_ref
9044