gene_symbol
ERBB4
hgnc_id
HGNC:3432
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Dacomitinib irreversibly inhibits HER4 tyrosine kinase, blocking MAPK/PI3K–AKT survival signaling and inducing growth arrest and apoptosis in HER4-dependent cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Irreversible covalent ATP-site inhibitor; pan-ERBB
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05834348
disease_id_num_tar_ref
3350
drug_id_num_tar_ref
9044