gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The HER2-binding ADC is internalized after binding HER2; linker cleavage releases MMAE inside the cell, disrupting microtubules to cause G2/M arrest and apoptosis. The antibody Fc can also mediate ADCC against HER2+ cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain binding by ADC antibody; induces internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06383533
disease_id_num_tar_ref
3357
drug_id_num_tar_ref
9063