gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
RC48 binds HER2, is internalized, and releases MMAE, which binds beta‑tubulin to disrupt microtubules and trigger G2/M arrest and apoptosis in HER2+ cells; beta‑tubulin expression alone is not targeted or sufficient for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Vinca-binding site targeted by MMAE payload; microtubule polymerization inhibitor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06383533
disease_id_num_tar_ref
3357
drug_id_num_tar_ref
9063