gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infused autologous TILs recognize tumor peptide–HLA via native TCRs and directly kill target cells by immunologic synapse formation with perforin/granzyme release (and Fas–FasL–mediated apoptosis), aided by cytotoxic cytokines.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Non-mutated melanoma-associated antigens; presented on HLA class I and/or II; recognized by TCRs on TILs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06151847
disease_id_num_tar_ref
3361
drug_id_num_tar_ref
9076