gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti–TROP-2 antibody–drug conjugate binds and is internalized; linker cleavage releases SN-38, a topoisomerase I inhibitor, causing DNA breaks and apoptosis in TROP-2–positive cells. Some extracellular SN-38 can also mediate bystander killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface transmembrane glycoprotein targeted by the hRS7 antibody component.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06081244
disease_id_num_tar_ref
3369
drug_id_num_tar_ref
9099