gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Trastuzumab deruxtecan targets HER2 for uptake; once internalized it releases a Top1‑inhibiting payload that causes DNA damage and apoptosis, with additional ADCC and bystander effects.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC payload (deruxtecan/DXd) inhibits TOP1
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06492447
disease_id_num_tar_ref
3371
drug_id_num_tar_ref
9103