gene_symbol
TNFRSF9
hgnc_id
HGNC:11924
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HLX35 agonizes 4-1BB on activated T/NK cells to costimulate them; the activated immune cells then kill EGFR-positive tumor cells. 4-1BB–expressing cells are not directly lysed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Conditional 4-1BB agonism when crosslinked via EGFR on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05442996
disease_id_num_tar_ref
3374
drug_id_num_tar_ref
9110