gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 on target cells and engages Fc gamma receptor–bearing immune cells (e.g., NK cells) to trigger antibody-dependent cellular cytotoxicity (ADCC); may also activate complement.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (subdomain IV); mediates Fc-dependent ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05583110
disease_id_num_tar_ref
3379
drug_id_num_tar_ref
9126