gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells bind CD19 on target cells and directly kill them via immunologic-synapse–mediated perforin/granzyme cytotoxicity (and death-receptor pathways), leading to apoptosis of CD19+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface B-cell lineage antigen; non-MHC/HLA-restricted CAR binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06635330
disease_id_num_tar_ref
3383
drug_id_num_tar_ref
9134