gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-EGFR IgG1 binds EGFR and its Fc engages FcγR+ immune effectors to mediate ADCC (NK/macrophage killing); may also trigger CDC. EGFR signaling blockade is cytostatic.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain binding; blocks ligand binding and activation; IgG1 Fc enables ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06429904
disease_id_num_tar_ref
3385
drug_id_num_tar_ref
9136