gene_symbol
ERBB3
hgnc_id
HGNC:3431
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER3 (and EGFR) on tumor cells, is internalized, and releases the topoisomerase I inhibitor brengitecan, causing DNA damage and tumor cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06437522
disease_id_num_tar_ref
3388
drug_id_num_tar_ref
9149