gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells, triggering direct caspase-independent cell death and engaging Fc-gamma RIIIa on effector cells to mediate ADCC and phagocytosis, leading to target-cell killing.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II epitope on the extracellular domain of CD20
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05783596
disease_id_num_tar_ref
3390
drug_id_num_tar_ref
9157