gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The antibody binds GD2 on tumor cells; its Fc engages FCGR3A (CD16a) on NK/myeloid cells to drive ADCC and phagocytosis, and activates complement (CDC), killing GD2+ cells rather than FCGR3A+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc region engagement mediating NK cell ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05558280
disease_id_num_tar_ref
3395
drug_id_num_tar_ref
9174