gene_symbol
FCGR2A
hgnc_id
HGNC:3616
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Dinutuximab beta binds GD2 on tumor cells; its Fc engages FCGR2A (CD32a) on immune effector cells to drive ADCC/phagocytosis and CDC against GD2+ targets. FCGR2A-expressing cells are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc region engagement mediating phagocytosis/ADCP (macrophages, neutrophils)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05558280
disease_id_num_tar_ref
3395
drug_id_num_tar_ref
9174