gene_symbol
FCGR1A
hgnc_id
HGNC:3613
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The antibody binds GD2 on tumor cells and engages CD64 (FCGR1A) on immune effector cells via its Fc to trigger ADCC/ADCP and complement killing of GD2+ cells; CD64-expressing cells are not directly targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
High-affinity Fcγ receptor on monocytes/macrophages (ADCP)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05558280
disease_id_num_tar_ref
3395
drug_id_num_tar_ref
9174